Amit Singh scientist : Department of Microbiology & Cell Biology of the Indian Institute of Science

Dr. Amit Singh is an esteemed Indian microbiologist, currently serving as an Associate Professor in the Department of Microbiology and Cell Biology at the Indian Institute of Science (IISc), Bangalore. His research primarily focuses on understanding the persistence mechanisms of human pathogens, notably Mycobacterium tuberculosis (Mtb) and the Human Immunodeficiency Virus (HIV).

Dr. Singh completed his Master's degree in Biotechnology from the Indian Institute of Technology Roorkee in 1998. He then pursued a Ph.D. in Biochemistry at the University of Delhi South Campus, where he conducted research under the guidance of Dr. Anil Kumar Tyagi. Following his doctoral studies, he undertook post-doctoral research at the University of Alabama at Birmingham in the laboratory of Dr. Adrie JC Steyn.

Professional Journey:

Upon returning to India in 2010, Dr. Singh joined the International Centre for Genetic Engineering and Biotechnology as a Wellcome Trust-DBT Intermediate Fellow. In January 2014, he became a part of IISc's Department of Microbiology and Cell Biology. At IISc, he leads the Centre for Infectious Disease Research, where his team investigates the fundamental mechanisms underlying the persistence and drug tolerance of pathogens like Mtb and HIV.

Research Contributions:

Dr. Singh's laboratory has made significant strides in understanding how redox signaling influences the persistence and drug tolerance of Mtb. By developing and utilizing genetically encoded biosensors, his team identified the role of redox heterogeneity in coordinating these processes. Notably, their research led to the discovery that chloroquine, a drug traditionally used to treat malaria, could be repurposed to accelerate tuberculosis treatment. This finding has progressed to phase II clinical trials.

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